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Association of Oral and Intestinal Microecology with Prognosis in Acute Ischemic Stroke: A Prospective Nested Case-Control Study

Exploring the oral and intestinal microbiota characteristics of phlegm-heat syndrome in acute ischemic stroke (AIS) based on 16S rRNA sequencing

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400080670
Enrollment
Unknown
Registered
2024-02-04
Start date
2024-02-05
Completion date
Unknown
Last updated
2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Stroke

Interventions

mRS=2:None
mRS>3:None
Healthy people group:None

Sponsors

Dongzhimen Hospital, Beijing University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: AIS group: 1) Diagnosis of acute ischemic stroke; 2) age > 18 years; 3) admission within 72 hours of AIS onset; 4) The patient has informed consent and signed an informed consent form. Healthy people group: 1) Residing in Beijing for more than 5 years; 2) Age>18 years old; 3) No cardiovascular or cerebrovascular diseases.

Exclusion criteria

Exclusion criteria: AIS group 1) Severe co-morbidities affecting survival, including tumors, massive gastrointestinal bleeding, and cirrhosis; 2) Unstable vital signs and coma; 3) Use of antibiotics, prebiotics or probiotics within the previous 1 month. Healthy people group: 1) Previously suffered from serious illnesses, including tumors, significant gastrointestinal bleeding, and cirrhosis; 2) Chronic inflammatory diseases, including gastritis, enteritis, hepatitis, periodontitis, etc; 3) Use antibiotics, prebiotics, or probiotics within the first month.

Design outcomes

Primary

MeasureTime frame
Modified Rankin Scale;

Secondary

MeasureTime frame
The National Institutes of Health Stroke Scale;Diagnostic Scale of Syndrome Elements in Ischemic Stroke (DSSEIS);Confusion assessment method;PAC-SYM;Barthel Index;

Countries

China

Contacts

Public ContactXinxing Lai; Gao Ying

Dongzhimen Hospital, Beijing University of Chinese Medicine

jiangping302@126.com+86 188 1092 3089

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026