cancer pain
Conditions
Interventions
single unit:pca titration of hydromorphone injection
single unit:Conversion to oxycodone extended-release tablet maintenance therapy after successful titration
Sponsors
Yichang Central People's Hospital, the First Clinical Medical College of Three Gorges University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) The subject voluntarily signs the informed consent for this experiment; 2) Imaging or histopathological diagnosis of malignant tumors; 3) Age 18-80 years old, clear consciousness, regardless of gender; 4) Persistent cancer pain, NRS score =4 in the past 24 hours; 5) Patients who had not received radiation therapy within 7 days prior to randomization and the trial; 6) ECOG-PS =3 points.
Exclusion criteria
Exclusion criteria: 1) The patient is diagnosed with non-cancerous pain or unexplained pain; 2) Patients with paralytic ileus; 3) Patients with severe neuropathic cancer pain and other refractory cancer pain; 4) Abnormal and clinically significant laboratory results, such as creatinine = 2 times the upper limit of normal, ALT or AST= 2.5 times the upper limit of normal (= 5 times the upper limit of normal in patients with liver metastasis or primary liver cancer), or Child C grade liver function; 5) Cognitive dysfunction; 6) Patients allergic to narcotic drugs; 7) Pregnant or lactating patients; 8) Participate in the drug test (including the drug in the test) within 1 month before the test; 9)Diseases and conditions that other researchers consider ineligible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Conversion success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Average daily pain score;Daily dose;Number of pain bursts;Patient quality of life;Satisfaction rating; | — |
Countries
China
Contacts
Public ContactHaibo Zhou
Yichang Central People's Hospital, the First Clinical Medical College of Three Gorges University
Outcome results
None listed