Sedation for diagnostic hearing examination in infants
Conditions
Interventions
dexmedetomidine with chloral hydrate (biased coin sequential method):Each child will be given 50mg/kg oral solution of 10% chloral hydrate.15 minutes later ,the child will be given nasal drops at a ca
If sedation of the former child is judged successful ,there is a 10% chance that the dose of dexmedetomidine in the latter child will be reduced by a gradient and a 90% chance that the original dose w
Sponsors
Jiangmen Women's and Children's Health Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: (1)children who are to undergo diagnostic hearing tests and require medium deep sedation;(2)the age ranges from 1 month to 12 months;(3) ASA grade ? ~ ?.
Exclusion criteria
Exclusion criteria: (1)premature infant;(2)allergic to chloral hydrate or dexmedetomidine;(3)nasal congestion,runny nose and other upper respiratory tract infection symptoms;(4)children with severe dysplasia and weight not reaching the normal range;(5)children with severe central nervous system,respiratory,circulation,liver and kidney dysfunction and other systemic diseases;(6)the children and their parents refused to accept the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 90% effective dose (ED90) of dexmedetomidine nasal drops in a compound oral solution of 50mg/kg 10% chloral hydrate for infant sedation in diagnostic examination of hearing.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay sedation score;cerebral state index;systolic pressure;heart rate;pulse oxygen saturation; | — |
Countries
China
Contacts
Public ContactWanting Li/ Haihong Deng
Jiangmen Women's and Children's Health Hospital
Outcome results
None listed