no limit
Conditions
Interventions
K1: Anesthesia was induced by intravenous injection of penehyclidine 0.5 mg, midazolam 0.04 mg/kg, cisatracurium 0.2 mg/kg, sufentanil 0.2 µg/kg, corresponding doses of ketamine 0.2 mg/kg group and ci
K2: Anesthesia was induced by intravenous injection of penehyclidine 0.5 mg, midazolam 0.04 mg/kg, cisatracurium 0.2 mg/kg, sufentanil 0.2 µg/kg, corresponding doses of ketamine 0.3 mg/kg group and ci
k3: Anesthesia was induced by intravenous injection of penehyclidine 0.5 mg, midazolam 0.04 mg/kg, cisatracurium 0.2 mg/kg, sufentanil 0.2 µg/kg, corresponding doses of ketamine 0.4 mg/kg group and ci
Sponsors
The first affiliated hospital of henan university of CM
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1)Can understand and sign informed consent forms, (2) aged 18-60 years, (3)ASA is classified as Grade I or II (4) BMI 18-28 kg/m^2, (5)There is no allergy or intolerance to the research medication; (6) general anesthesia with laryngeal mask airway (LMA) , (7)Not involved in other clinical studies.
Exclusion criteria
Exclusion criteria: (1) pregnant women, (2) history of asthma, (3) alcohol abuse, (4) heart, liver and kidney dysfunction, (5) patients with mental disorders and communication disorders, (6) patients with poorly controlled or untreated hypertension; (7) Patients who have taken psychiatric or opioid drugs intermittently within the past 3 months or continuously within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;The occurrence of body movements and laryngeal spasms;Rating of ease of placement of laryngeal mask;VAS pain score; | — |
Countries
China
Contacts
Public ContactZhang Yi
No.19 Renmin Road, Zhengzhou City, Henan Province
Outcome results
None listed