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Mechanism of intestinal flora metabolites on intestinal function recovery in patients with gastric cancer under ERAS concept

Mechanism of intestinal flora metabolites on intestinal function recovery in patients with gastric cancer under ERAS concept

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400080616
Enrollment
Unknown
Registered
2024-02-02
Start date
2024-02-15
Completion date
Unknown
Last updated
2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastric Cancer

Interventions

Trail group:ERAS

Sponsors

Affiliated Hospital of Jiangsu University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients diagnosed with gastric cancer through pathological examination; (2) Age 18-80 years old; (3) Prior to this experiment, no surgery, radiotherapy, chemotherapy, or other treatments were received; (4) No use of antibiotics in the short term (5)The patient and his family members informed consent to this study, and signed an informed consent form

Exclusion criteria

Exclusion criteria: 1) Those who are deemed unsuitable to participate in this trial by a physician; 2) Patients with ischemic heart disease, cerebrovascular disease, and peripheral vascular disease, patients with heart function>Level II (NYHA), patients who have recently undergone CABG surgery, and patients with severe hypertension (systolic blood pressure = 180mmHg or diastolic blood pressure = 110mmHg); 3) Patients with distant metastasis of the tumor; 4) Patients with severe infection, respiratory dysfunction, coagulation dysfunction, and severe liver and kidney dysfunction (Child Pugh = 10 points; creatinine clearance rate10%, or SGA nutritional status evaluation grade C, BMI<18, Hb<70g/L); 9) Used antibiotics or supplemented probiotics before the experiment; 10) Patients with severe edema, infection, and peripheral blood circulation disorders; 11) Pregnant and lactating women, subjects (including male subjects) who have a pregnancy plan within one month after the trial, 12) are unable to complete accelerated rehabilitation surgery procedures or have obvious contraindications to accelerated rehabilitation surgery; 13) Participate in other clinical trials within 3 months prior to the trial; 14) Applicants or researchers directly participating in the experiment or their family members.

Design outcomes

Primary

MeasureTime frame
The amount of tryptophan in feces ;The amount of indole in feces ;Structure and quantity of gut microbiota ;

Secondary

MeasureTime frame
Postoperative complication rate ;hospital stay ;Hospitalization expenses; Immune indexes;Inflammatory indexes;Nutritional indexes;The recovery of intestinal function;

Countries

China

Contacts

Public ContactFan Xin

Affiliated Hospital of Jiangsu University

drfanxin@163.com+86 139 5280 3788

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026