Syphilis with Serum Fixation
Conditions
Interventions
test group:Ceftriaxone 2 g / day for 14 days, IL-2 500000 U / time (dissolved in 2ml injection water) 3 times a week for 6 weeks
control group:Ceftriaxone 2 g / day for 14 days, Placebo (2ml injection water) 3 times a week for 6 weeks
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) the patients who are 18-60 years old, regardless of gender; (2) the patients who had received regular antisyphilis treatment; (3) the rapid plasma Reagin ring card test (RPR/TRUST) did not turn negative for stage I syphilis with complete follow-up data for more than one year, or for stage II syphilis with complete follow-up data, the rapid plasma Reagin ring card test (RPR/TRUST) did not turn negative for more than 2 years. Or the patients with advanced syphilis were regularly treated with syphilis for more than 3 years, and the rapid plasma Reagin ring card test (RPR/TRUST) did not turn negative. (4) the patients who were willing to cooperate with this project signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) patients with syphilis reinfection; (2) patients with recurrent syphilis; (3) patients less than 18 years old or more than 60 years old; (4) patients with severe heart and liver (heart function is divided into 4 grades, belonging to grade 3-4; ALT > normal value 1.5 times), renal insufficiency (Cr > 133umol/L) or hematopoietic dysfunction, bleeding tendency and hemorrhagic diseases. And patients with malignant tumors, mental illness, rheumatoid disease, systemic lupus erythematosus and other medical diseases; (5) those who have been treated with ceftriaxone sodium because of serum fixation in the past; (6) those who have used immunosuppressants such as corticosteroids for various reasons within the past month; (7) those who are allergic to benzylpenicillin or / and ceftriaxone; (8) pregnant or lactating women; (9) immunocompromised patients. (10) drug addicts; (11) those who are participating in other clinical trials; (12) those who are not easy for long-term follow-up or poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serological examination of syphilis(RPR/TRUST); | — |
Secondary
| Measure | Time frame |
|---|---|
| Comprehensive curative effect evaluation; | — |
Countries
China
Contacts
Public ContactZhou Ying
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed