arthroscopic rotator cuff repair
Conditions
Interventions
group S1:the high-dose esketamine group (group S1) received 0.5 mg/kg esketamine diluted with normal saline to 10 mL by intravenous injection over 1 minute before surgical incision, followed by at a r
group S2:the low-dose esketamine group (group S2) received 0.25 mg/kg esketamine diluted with normal saline to 10 mL by intravenous injection over 1 minute before surgical incision, followed by at a r
group C:the control group (group C) received equal volume of normal saline.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) age = 18 years old; (2) ASA physical status I–III; (3) BMI 18-30; (4)planning elective general anesthesia for Arthroscopic shoulder surgery; and (5) voluntary signed informed consent by the patient or their legal guardian.
Exclusion criteria
Exclusion criteria: (1) An established mental illness; (2) Patients with preoperative cognitive or language impairments that hindered communication;(3) Patients with a history of chronic pain or opioid abuse before surgery; (4) drug and/or alcohol abuse within the last 3 months, defined as consuming an average of more than 2 units of alcohol per day (1 unit =360ml of 5% beer or 45ml of 40% liquor or 150 ml of wine); (5) postoperative admission to the ICU;(6)allergy to the active ingredient or excipient of S-ketamine hydrochloride injection; (7) contraindications for esketamine use including a risk for serious rise in blood pressure or intracranial pressure, high intraocular pressure(glaucoma), poorly controlled hypertension(resting systolic blood pressure greater than180mmHgor resting diastolic blood pressure greater than100 mmHg) , untreated/undertreated hyperthyroidism ; (8) Male or Female with family planning;(9) involvement in other drugs or medical devices of clinical research for a duration of approximately three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the quality of recovery scores based on the QoR-15 scale on POD1; | — |
Secondary
| Measure | Time frame |
|---|---|
| the quality of recovery scores based on the QoR-15 scale on POD3;cerebral desaturation events(CDEs);the consumption of remifentanil;rescue analgesia after surgery;NRS pain scores on POD1 and POD2;The quantity of vasoactive medications administered during the procedure;Postoperative delirium developed at 24, 48, and 72 hours after surgery(3D-CAM scale); | — |
Countries
China
Contacts
Public ContactQirong Sun/Leng Zhou
West China Hospital, Sichuan University
Outcome results
None listed