Aneurysmal subarachnoid hemorrhage
Conditions
Interventions
LDITUK group:Standard treatment+lumbar cistern drainage+intrathecal urokinase injection
control group:Standard treatment+lumbar cistern drainage
Sponsors
The Second Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: -Patient’s age = 18 years - First occurrence of aneurysmal subarachnoid hemorrhage - Patients without any craniotomy treatment before onset - Hunt-Hess grade III-V - mRS grade 0 or 1 before onset - Aneurysm treatment within 48 hours of onset - Informed consent given by the subject or guardian
Exclusion criteria
Exclusion criteria: - Subarachnoid hemorrhage caused by arteriovenous malformation or moyamoya disease or other cerebrovascular disease - modified Fisher Scale grade 0 - Prothrombin time (PT) and activated partial thromboplastin time (APTT) are less than 2 times the extended range - Absolute contraindications for lumbar puncture (e.g., brain hernia, puncture site infection) - Patients with a life expectancy of less than 1 year due to other causes - Other concomitant serious diseases that are difficult to treat; - Pregnant woman - Patients who were known to be allergic to urokinase and excipients or had a history of severe allergy and were deemed unsuitable for inclusion by the investigators - Participated in another interventional clinical trial within 30 days before randomization - Other reasons deemed unsuitable for study participation by the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS score of 0~2; | — |
Secondary
| Measure | Time frame |
|---|---|
| mRS score of 0~6;Cerebral vasospasm incidence;Delayed cerebral ischemia incidence;All-cause mortality;Shunt dependent hydrocephalus incidence;Aneurysm rerupture incidence;Length of stay;Hospitalization expenses;mRS score of 0~2 Rates; | — |
Countries
China
Contacts
Public ContactXingen Zhu
The Second Affiliated Hospital of Nanchang University
Outcome results
None listed