Kneed Osteoarthritis
Conditions
Interventions
1. Conventional use of IPACK group:Ropivacaine is routinely used for nerve blocks
2. Modified IPACK group with dexmedetomidine:Add dexmedetomidine for nerve block
Sponsors
Xi’an Honghui Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: (1) The age of the patient is 18-100 years old (including the boundary value); (2) The patient requires knee arthroplasty due to knee osteoarthritis.
Exclusion criteria
Exclusion criteria: (1) BMI >30; (2) pain in the knee associated with allergy to the study drug and changes in nerve damage; (3) Ongoing antipsychotic medication, history of bipolar disorder and schizophrenia, and other conditions that the investigator deems unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Dosage of morphine within 24 h after surgery;Total morphine use during hospitalization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster University Osteoarthritis Index (WOMAC);Quality of recovery-15 score;Times of sleep interruption due to pain on the night of surgery;Postoperative adverse events; | — |
Countries
China
Contacts
Public ContactLi Zheng
Department of Joint Surgery,Xi’an Honghui Hospital
Outcome results
None listed