Allergy-related diseases
Conditions
Interventions
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: (1) Term infants are 37= gestational age < 42 weeks, and the birth weight is between 2500g and 4000g (only applicable to 0~12 months old); (2) Breastfed or mixed-fed healthy infants and young children, aged 0~3 (inclusive) years old, gender is not limited; (3)The allergy risk score calculated by the Infant Allergy Risk Assessment Table is =6(Refer to the National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention: Investigation and Research on Allergy Symptoms and Risk Factors in Infants and Young Children). (4) Family primary guardians agree to collect fecal samples of infants and young children during this study; (5) Have not used antibiotics in the past month (6) Have not used probiotics in the past three months (7) Family primary guardians committed not to add additional Bifidobacterium dietary supplements to infants and young children during the intervention period; (8) The guardians of the enrolled subjects agree to participate in this interventional study and sign a written informed consent form, and are able to understand and fill in forms such as infant diaries as required; (9) Signed informed consent and willing to follow up at the time specified in the trial
Exclusion criteria
Exclusion criteria: (1) The mother of the infant has a history of diabetes, hepatitis B, HIV and other infectious diseases; (2) Clinicians diagnosed with allergic diseases (including but not limited to eczema, asthma, allergic proctocolitis, allergic rhinitis, hay fever, etc.) at the time of enrollment of infants and young children; (3) Infants and young children who are known to be allergic to the ingredients of probiotic products; (4) In the opinion of the investigator, the subject has other reasons that make it unsuitable to participate in this clinical study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of allergies; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal flora;Calprotectin;secretory immunoglobulin A;human ß-defensin 2 ;Antimicrobial Peptide LL-37;height;weight;Head circumference;Defecation situation;Incidence of non-allergic disease; | — |
Countries
China
Contacts
Public ContactZhang Jinping
Shanghai Sixth People's Hospital
Outcome results
None listed