total hip replacement
Conditions
Interventions
Group P:propofol
Sponsors
The First Affiliated Hospital of Gannan Medical College
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 60-80 years old; 2. ASA I-III level; 3. Able to speak Mandarin and communicate, with education level > 9 years; 4.Preoperative mini-mental state examination ( MMSE ) > 26 ; 5. Heart, lung, liver, and kidney functions have no obvious abnormalities; 6.Get informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative cognitive impairment, patients with a history of dementia and delirium; 2. Patients with severe depression, schizophrenia and other mental and nervous system diseases or who have taken antipsychotic or antidepressant drugs; 3. Use of anti-inflammatory drugs, glucocorticoids or other hormonal drugs, alcohol or drug dependence; 4. Hearing or visual impairment cannot complete the test score; 5.Allergic to related drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bispectral index;Silence information regulator 3;Neuron-specific enolase;S100ß; | — |
Countries
China
Contacts
Public ContactWang Lifeng
The First Affiliated Hospital of Gannan Medical College
Outcome results
None listed