Effect of Esketamine on Postoperative Anxiety in Patients Undergoing Dilatation and Curettage after Missed Abortion during in Vitro Fertilization Treatment
Conditions
Interventions
Group C (saline group, 0.1ug/kg sufentanil + propofol 1mg/kg):None
Group E1 (sufentanil + 0.2mg/kg esketamine + propofol):None
Group E2 ( sufentanil + 0.35mg/kg esketamine +propofol):None
Group E3 (sufentanil + 0.5mg/kg esketamine +propofol):None
Sponsors
Sichuan Jinxin Xi'nan Women's and Children's Hospital
Eligibility
Sex/Gender
Female
Age
23 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) Diagnosed with infertility and undergoing IVF treatment at our hospital; 2) Age 23-45; 3) Comply with the diagnostic standards for induced abortion; 4)ASA I-II; 5) elective surgery of painless curettage; 6) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients with preoperative psychiatric dysfunction and those taking psychotropic medications preoperatively; 2) Allergy to the drugs involved in this study; 3) Severe cardiac, pulmonary, hepatic and renal organ insufficiency; 4) History of upper respiratory tract infection in the last 2 weeks; 5) Poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure over 180/100 mmHg); 6) Patients with hyperthyroidism and those at risk of increased intracranial pressure; 7) History of psychotropic drugs, opioids, and alcohol dependence; 8) Taking benzodiazepines or opioids during the last 3 months; 9) Participation in clinical trials of other drugs within the last 3 months; 10) Communication barriers; 11) Change in anaesthesia; 12) Patients and their families refused to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of anxiety ;Pregnancy outcomes; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe anxiety;The incidence anxiety;SAS score;SDS score;The incidence of depression;Incidence of intraoperative body movements;Incidence of respiratory depression;Intraoperative circulatory fluctuations;Postoperative NRS scores;Postoperative remedial analgesic dose;Postoperative adverse events;Length of stay in PACU;Wake-up time;Intraoperative propofol dose; | — |
Countries
China
Contacts
Public ContactNI JUAN LI
Sichuan Jinxin Xi'nan Women's and Children's Hospital
Outcome results
None listed