The effect of probiotics combined with dietary fiber on intestinal mucosal barrier function and prognosis in patients with sepsis

The effect and mechanism of probiotics combined with dietary fiber on intestinal mucosal barrier function in sepsis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400080526

Enrollment

Unknown

Registered

2024-01-31

Start date

2024-03-16

Completion date

Unknown

Last updated

2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis

Interventions

Treatment Group:probiotics combined with dietary fiber

Control Group:None

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients who were admitted to Intensive Care Unit of Hebei General Hospital during the study period and met the following conditions: 1. >18 years old 2.Sepsis 3.intestinal microflora disruption

Exclusion criteria

Exclusion criteria: 1. Receiving treatment with other probiotics or dietary fiber 2. Expected to receive intervention treatment for less than 7 days 3. Severe gastrointestinal diseases or strict fasting after surgery 4. Severe immune dysfunction 5. Liver and kidney dysfunction (Child-Pugh grade C; chronic kidney disease stage 4-5, even requiring renal replacement therapy).

Design outcomes

Primary

Measure	Time frame
gut microbial composition;short-chain fatty acid;	—

Secondary

Measure	Time frame
Inflammation;immune function;Incidence of enteritis;Incidence of bloodstream infection;28d mortality rate;	—

Countries

China

Contacts

Public ContactLing Long

Hebei General Hospital

longlin77@126.com+86 181 3208 0429

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026