Breast cancer
Conditions
Interventions
Thymus protection group:The thymus is delineated in the target area of adjuvant radiotherapy patients after breast cancer surgery, and the dose volume is limited.
Control group:Do not delineate the thymus as an organ at risk
Sponsors
The Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.1 Females aged 18-75 years; 1.2 Breast cancer patients with pathological diagnosis requiring postoperative adjuvant radiotherapy; 1.3 The hematopoietic function and liver, kidney, heart and lung function of the patient are acceptable, (white blood cell > 2.5*109/L, platelet > 50*109/L, bilirubin not more than 1.5 times the upper limit of normal, liver function alanine aminotransferase and aspartate aminotransferase not more than 2.5 times the upper limit of normal, and renal function creatinine not more than 1.5 times the upper limit of normal); 1.4 The patient activity status score was 0-1 points based on the Eastern Cooperative Oncology Group (ECOG) score method, and the functional status evaluation score was =70 points by the Karnofsky (KPS) score method. 1.5 All of them have indications for postoperative radiotherapy and chemotherapy, and have not yet undergone a full course of radiotherapy; 1.6 No distant metastases occurred at the time of diagnosis; 1.7 Able to sign written informed consent by the patient himself/herself.
Exclusion criteria
Exclusion criteria: 2.1Patients with bilateral breast cancer; 2.2 Radiotherapy at all doses has been completed; 2.3 Presence of a second primary tumor; 2.4 Pregnant and lactating women; 2.5 presence of distant metastases; 2.6 Male breast cancer patients; 2.7 Previous sternotomy for various reasons; 2.8 Use of thymosin during treatment; 2.9 Presence of autoimmune diseases (such as myasthenia gravis, systemic lupus erythematosus, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute lymphocyte count; | — |
Secondary
| Measure | Time frame |
|---|---|
| The absolute count of T lymphocytes;naive CD4 and CD8 T cells;CD4+, CD8+ activated effector memory cells and central memory cells; | — |
Countries
China
Contacts
Public ContactCai Shang
The Second Affiliated Hospital of Soochow University
Outcome results
None listed