Knee Osteoarthritis
Conditions
Interventions
Intervention Group:Injected with 40 mg (1 mL) of triamcinolone acetonide hydrochloride into the subpatellar fat pad under ultrasound guidance
Control Group:Injected with 40 mg (1 mL) of triamcinolone acetonide hydrochloride into the knee joint cavity under ultrasound guidance.
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Above 40 years old; 2. Patients with unilateral knee joint pain; 3. The WOMAC pain score (range 0-20 points) on this side in the past week was 8-18 points; 4. This side meets the ACR clinical classification criteria for knee osteoarthritis; 5. KL >= 2 on this side 6. MRI examination of this side shows Hoffa’s synovitis; 7. Patients who are scheduled to reveive intra-articular steroid injection treatment.
Exclusion criteria
Exclusion criteria: 1. Accompanied by rheumatoid arthritis, gouty arthritis and other diseases that affect lower limb symptom scores; 2. Have been scheduled to undergo joint surgery; 3. Patients who have had surgery in the knee joint in the past; 4. Taking oral glucocorticoid drugs; 5. Patients who have received intra-articular glucocorticoid injection in the past 6 months; 6. Allergy to glucocorticoids; 7. Have contraindications for MRI examination; 8. Patients with type I or type 2 diabetes with poor blood sugar control; 9. Patients with a history of peptic ulcer; 10. Unable to complete follow-up and questionnaire surveys independently; 11. Patients who are unwilling to join the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Superiority indicator: Difference in Hoffa’s synovitis improvement rate between the two groups based on the MOAKS scoring system;Non-inferiority indicator:The difference in improvement in WOMAC pain scores (0-20 points) between the two groups ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in Hoffa’s synovitis improvement rate between the two groups based on the MOAKS scoring system;The difference in improvement in WOMAC pain scores (0-20 points) between the two groups ;NRS pain questionnaire scores;WOMAC questionnaire scores (function, joint stiffness and total scores);Improvement rate of effusion synovitis (according to MOAKS system);Articular cartilage thickness changes (MRI quantification);ICOAP questionnaire scores;EQ5D questionnaire scores;OARSI-OMERACT response rate; | — |
Countries
China
Contacts
Public ContactWang Qiuke
Shanghai Sixth People's Hospital
Outcome results
None listed