septic acute lung injury
Conditions
Interventions
Oxycodone hydrochloride group:Intravenous infusion of oxycodone hydrochloride injection 5 minutes prior to endotracheal intubation for mechanical ventilation
Sufentanil Injection group:Equivalent doses of sufentanil injection (1:0.001) were administered intravenously using a venous pump
Sponsors
Tianjin Nankai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years old, gender and ethnicity are not limited; (2) All patients diagnosed to meet with the Sepsis 3.0 criteria and the International Consensus Guidelines for Septic Shock: Diagnostic criteria for septic acute lung injury included the corresponding history of primary disease; clinical symptoms of breathing difficulty or distress; Hypoxemia, is classified as follows based on the PaO2/FiO2 ratio under positive end-expiratory pressure (PEEP) of at least 5cmH2O: 200mmHg <PaO2/FiO2=300mmHg(Mild) ; 100mmHg< PaO2/FiO2= 200mmHg(Moderate) ; PaO2/FiO2= 100mmHg(Severe) ; chest radiographs showed bilateral pulmonary infiltration; insertion of an endotracheal catheter for positive-pressure ventilation was required; and there was no clinical evidence of left atrial hypertension to account for the bilateral pulmonary infiltration(or pulmonary wedge pressure= 18 mmHg). 3) Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Refuse to participate in this study; 2) People with opioid allergy; 3) A history of narcotic analgesic drugs abuse; 4) Pregnant and lactating women; 5) Concurrent use of monoamine oxidase inhibitors or within 2 weeks after discontinuation; 6) Moderate to severe liver function impairment; 7) Severe renal function impairment with creatinine clearance <10 ml/min; 8) Currently being included in another study; 9) The attending physician or investigators consider that there are other inappropriate circumstances for participating in this study (reasons should be recorded).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Monitor blood gas analysis before and after drug administration, and calculate oxygenation index (PaO2/FiO2), respiratory index and PA-aO2;Record the change of lung injury scores after intubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Record APACHE-II scores, Murray scores and SOFA scores;Record the duration of mechanical ventilation, extubation time, and PEEP pressure changes.;Record the number of ICU days, total hospital days, postoperative complications, ICU mortality, and hospital mortality;Detect the changes in WBC, CRP, PCT, Lac, and PH before and after drug administration;Determine the changes of HO-1 activity and CC-16 activity in the serum of patients before and after drug administration;Record the number of patients with organ failure, and adverse events; | — |
Countries
China
Contacts
Public ContactYu Jianbo
Tianjin Nankai Hospital
Outcome results
None listed