melasma
Conditions
Interventions
Experimental group:fractional microneedle radiofrequency therapy combined with autologous platelet rich plasma injection
Control group:fractional microneedle radiofrequency therapy combined with saline
Sponsors
Dermatology Department of the First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Stable stage chloasma (non inflammatory erythema period); 2. Patients aged 18-60; 3. Agree to follow the experimental treatment plan and visit plan, voluntarily enroll, and sign an informed consent form in writing.
Exclusion criteria
Exclusion criteria: 1. Any uncontrollable serious or potentially affecting clinical system disease history/surgical history for treatment and effectiveness evaluation, such as circulatory system, nervous system, hematological system, immune system, mental system diseases, etc; 2. During the treatment period, receive other facial rejuvenation treatments; 3. Exposure to sunlight without protective measures during treatment; 4. Have a history of malignant tumors; 5. Have undergone major surgery within the first 3 months of screening, or plan to undergo major surgery during the trial period; 6. Individuals who have participated or are currently participating in clinical trials of other intervention drugs or medical devices within the first 3 months of screening; 7. Screening for drugs that affect the condition of melasma or have photosensitive properties, such as other phototherapy, oral methotrexate, glutathione, oral contraceptives, isotretinoic acid, minocycline, etc., received within the first three months of screening; 8. The researcher believes that the subject has other situations that may affect compliance or be unsuitable for participation in this study; 9. Individuals with a history of drug abuse, drug use, or alcohol dependence before screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified melasma area and severity index;VISIA image analysis system;Physician's global assessment, PGA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subject self-evaluation; | — |
Countries
China
Contacts
Public ContactChen Jin
Dermatology Department of the First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed