Esophageal Cancer
Conditions
Interventions
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) The gold standard for diagnosis of esophageal cancer patients who visited between January 2012 and December 31, 2024 is preoperative biopsy or postoperative pathological results confirming esophageal cancer; 2) Age range from 18 to 70 years old; 3) The clinical staging is stage II-IVa (8th edition UICC); 4) Potential surgical resection, planned to receive neoadjuvant chemotherapy and surgery; 5) PS score = 1; 6) The function of important organs meets the following requirements: white blood cells = 4.0 × 109/L, neutrophils = 1.5 × 109/L, platelet = 100.0 × 109/L, hemoglobin = 90g/L; Serum albumin = 2.8g/dL; Total bilirubin = 1.5 × ULN, ALT/AST/AKP = 2.5 × ULN; Serum creatinine = 1.5 × ULN or creatinine clearance rate>60 mL/min; Not complicated with severe organic diseases; 7) Dynamic enhanced CT, multi parameter MRI, and endoscopic ultrasound examinations were completed before and after neoadjuvant therapy.
Exclusion criteria
Exclusion criteria: 1) Accept palliative treatment; 2) Have a history of chest radiation therapy or have received esophageal radiotherapy, chemotherapy, or surgical treatment (excluding diagnostic biopsy); 3) Patients with severe comorbidities and inability to tolerate anti-tumor therapy; 4) The patient has contraindications that they cannot accept CT and MRI examinations; 5) The images before and after neoadjuvant therapy show significant deformation or artifacts; 6) Severe esophageal obstruction leading to failure to undergo endoscopic ultrasound examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of curative effect;Objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall Survival;Progression-Free Survival; | — |
Countries
China
Contacts
Public ContactHaojiang Li
Sun Yat-sen University Cancer Center
Outcome results
None listed