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Immune lymphocyte subsets predict the efficacy of immune checkpoint inhibitors in the treatment of hepatocellular carcinoma

Immune lymphocyte subsets predict the efficacy of immune checkpoint inhibitors in the treatment of hepatocellular carcinoma

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400080409
Enrollment
Unknown
Registered
2024-01-29
Start date
2021-12-27
Completion date
Unknown
Last updated
2024-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

Observation group:NA

Sponsors

Air Force Medical Center, PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: ? Patients with CNLC - stage III / bclc-c hepatocellular carcinoma; ? Liver function grade child Pugh A; ? ECOG-ps 0 or 1 point; ? 18-75 years old; ? The expected survival time was more than 3 months; ? There was no history of gastrointestinal bleeding in recent 6 months; ? No previous PD-1 antibody treatment; ? For patients beyond the above inclusion criteria, exploratory treatment can be carried out gradually according to the specific situation; ? Sign the informed consent form and agree to participate in the clinical study.

Exclusion criteria

Exclusion criteria: ? PD-1 antibody was used before the study. ? The basic constitution is extremely weak, so it is impossible to take clinical programs other than conservative treatment. ? Have a history of autoimmune diseases.

Design outcomes

Primary

MeasureTime frame
odds ratio;

Secondary

MeasureTime frame
objective response rate;

Countries

China

Contacts

Public ContactChengli Liu

Air Force Medical Center, PLA

liuchengli@tom.com+86 10 6692 8312

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026