spinal cord injury
Conditions
Interventions
Sponsors
Xijing Hospital, the First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients: 1. 18-70 years old, right hand dominant (Edinburgh Handedness Inventory); 2. has been diagnosed with SCI; 3. post-injured course of disease: the cross-sectional study is limited to 36 months, and the cohort study is limited to 1 week to 1 month (has passed the spinal shock period); 4. The patient did not receive any form of rTMS treatment within 2 weeks; 5. no cognitive impairment (Mini-Mental State Examination>=24 scores); 6. Patients in NP group also need to meet the following requirements: ? definite diagnosis of neuropathic pain according to NeuPSIG/IASP grading system; ? new pain caused by spinal cord injury; 7. agree to participate in this experiment and sign the informed consent form. Healthy controls: 1. 18-70 years old, matched with SCI patients; 2. right hand dominant (Edinburgh Handedness Inventory); 3. no cognitive impairment (Mini-Mental State Examination>=24 scores); 4. agree to participate in this experiment and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Patients:1. severe cognitive or language impairment; 2.the presence of conductive, ferromagnetic or other magnetically sensitive metals in the head or neck or the presence of a pacemaker; 3. seizures within the last six months; 4. serious local or systemic diseases, unable to tolerate relevant tests; 5. other types of pain (such as skeletal muscle pain, visceral pain and other non-neuropathic pain); 6. taking the drugs that may affect the MEP recording within 1 week, including baclofen, diazepam and other drugs; 7. female patients are in the menstrual period. Healthy controls:1.the presence of conductive, ferromagnetic or other magnetically sensitive metals in the head or neck or the presence of a pacemaker;2.present history of acute or chronic pain;3.taking the drugs that may affect the MEP recording within 1 week, including baclofen, diazepam and other drugs; 4. female patients are in the menstrual period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single pulse transcranial magnetic stimulation, spTMS;Paired pulsed transcranial magnetic stimulation, ppTMS;Functional near-infrared spectroscopy, fNIRS;High-density electroencephalogram, hdEEG;Numeric rating scale, NRS;Short-form MeGill pain questionnaire-2, SF-MPQ-2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Magnetic Resonance Spectroscopy,MRS;Somatosensory evoked potential, SEP;DN4 Neuropathic Pain Scale;Mechanical pain threshold;Pain and temperature threshold;Dynamic mechanical allodynia, DMA;Hyperpathia;Location and extent of pain; | — |
Countries
China
Contacts
Public ContactHua Yuan
Xijing Hospital, the First Affiliated Hospital of Air Force Medical University
Outcome results
None listed