Non-Acute Stroke Patients with Tracheostomy Lung Infections
Conditions
Interventions
Pseudomonas aeruginosa pulmonary infection group:None
Klebsiella pneumoniae pulmonary infection group:None
Acinetobacter baumannii pneumonia infection group:None
No pulmonary infection group:None
Healthy group:None
Sponsors
The Second People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: "This project plans to enroll patients with pulmonary infections as well as those without pulmonary infections who have undergone tracheotomy following non-acute stroke, using peripheral blood serum samples. The inclusion criteria are as follows: (1) Stroke diagnosis confirmed by MRI or CT; (2) Duration of stroke =1 month (non-acute phase); (3) Age =18 years; (4) Tracheotomy patients not requiring mechanical ventilation; (5) Pulmonary infection inclusion criteria based on the '2018 Chinese Adult Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia Diagnosis and Treatment Guidelines'. The presence of pulmonary infection is determined by the following standards; (6) Pulmonary infection diagnostic criteria: the appearance of new or progressive infiltrates, ground-glass opacity, or consolidation on chest CT or X-ray, along with at least two of the following clinical symptoms qualifies as a pulmonary infection: (a) body temperature >38.0 °C; (b) peripheral blood leukocyte count >10×10^9/L or <4×10^9/L; (c) purulent airway secretions. (7) Classification of pulmonary infection types based on sputum culture results: the presence of the same bacterial strain in at least two sputum culture results will be identified as the pathogen, categorized into Pseudomonas aeruginosa pulmonary infection group (PAPI), Klebsiella pneumoniae pulmonary infection group (KPPI), Acinetobacter baumannii pneumonia infection group (ABPI), and the no pulmonary infection group (NPI).
Exclusion criteria
Exclusion criteria: Exclude the influence of other diseases and medications; individuals with a history of psychiatric illness or functional impairments in mental or cognitive abilities; patients with severe dysfunction of the heart, lungs, liver, or kidneys; individuals with a history of severe allergic diseases or allergic constitution; patients with concomitant malignant tumors, immunodeficiency, or other serious illnesses; those who have been using non-steroidal anti-inflammatory drugs (NSAIDs) or steroids for an extended period; and non-cooperative participants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokine; | — |
Countries
China
Contacts
Public ContactGuo Jie
The second people's hospital of Shenzhen
Outcome results
None listed