Acute pancreatitis
Conditions
Interventions
linaclotide group:In the linaclotide group, participants received 1pill linaclotide oral once daily before breakfast in addition of routine treatment,and stopped taking it after 7 days.
Rhubarb group:50g raw rhubarb was added into 100ml warm boiled water, twice a day, orally) on the basis of conventional treatment
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Adult patients with AP (aged 18–75 years) were recruited. The time from AP onset to enrollment was restricted to 48 h. Participants complicated with GI dysfunction, which was defined as score of gut dysfunction (SGD) =5. Signed informed consent.
Exclusion criteria
Exclusion criteria: pregnant women,have already participated in other clinical trials,malignancy,chronic pancreatitis,peptic ulcer,mechanical intestinal obstruction,Inflammatory bowel diseases and other diseases which can cause chronic abdominal pain,patients with organ failure(score of Marshall =2),and patients who didn't sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| score of gut dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| D-lactic acid;pocalcitonin;damine oxidase;C-reactive protein;tumour necrosis factor-a;interleukin-6;interleukin-1 beta;the composition of gut microbiota;total enteral nutrition tolerance rate ;the number of days that can tolerate total enteral nutrition;the score of abdominal pain;Utilization rate of anodynes during the course of the disease;Incidence of infection during the course of the disease;incidence of transient or persistent organ failure after admission;the rate of minimally invasive medical intervention or surgical intervention;proportion of various severity of pancreatitis;the rate of transfering to ICU;total hospitalization days;drug taste score; | — |
Countries
China
Contacts
Public ContactHuifang Xiong
The First Affiliated Hospital of Nanchang University
Outcome results
None listed