colorectal cancer
Conditions
Interventions
Group T:Deep muscle relaxation conditions, Low pneumoperitoneum pressure˜8mmHg
Group C:Routine muscle relaxation conditions, Standard pneumoperitoneum pressure˜14mmHg
Sponsors
Beijing Luhe Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Elderly patients, aged 60 years (inclusive) to 80 years (inclusive), ASA classification does not exceed grade III. Body mass index (BMI) is within a certain range (18.5 ~ 30kg/m2). ? Patients who require laparoscopic radical resection of colorectal cancer under general anesthesia and can tolerate surgery. ? Patients with good compliance, postoperative visits can cooperate, and no cognitive dysfunction before surgery. ? With the approval of the Ethics committee of our hospital, obtain the consent of the patient and sign the informed consent. For patients who cannot understand their condition, informed consent is signed by their client.
Exclusion criteria
Exclusion criteria: ? Patients with mental illness, long-term use of psychotropic drugs such as diazepam, anti-anxiety, and alcohol or drug abuse; Patients with neurological diseases such as dementia and Parkinson's disease, and previous history of cerebrovascular accidents or craniocerebral surgery; Patients with severe visual or hearing impairment, illiteracy, and difficulties in language communication; Patients with obvious liver and kidney dysfunction, serious cardiopulmonary disease; Patients who are allergic to or have contraindiations with benzodiazepines, opioids, lidocaine and drug components. ? patients with anemia (hemoglobin less than 90g/L) ? patients with serious complications and surgical failure during perioperative period, patients with intraoperative blood loss > 200ml. (3) Neuromuscular conduction dysfunction, patients who took drugs known to affect neuromuscular conduction function before surgery, patients with contraindications to neostigmine and atropine, and patients who could not successfully extubation after surgery. ? Patients with poor temporal window penetration were examined by transcranial Doppler before operation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| rsO2;Pulse index, PI; Resistance index, RI;Montreal Cognitive Assessment, MoCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glial fibrillary acidic protein (GFAP);S100ß;neuron specific enolase (NSE);IL-6;TNF-a; | — |
Countries
China
Contacts
Public ContactZHILI JING
Beijing Luhe Hospital Capital Medical University
Outcome results
None listed