Alzheimer’s disease, Mild Cognitive Impairment, Subjective Cognitive Decline
Conditions
Interventions
Group social group:Conduct comprehensive social intervention for 3 times/week and 90 minutes/time, consisting of 25 minutes of collective discussion, 35 minutes of collective aerobic dance and 30 minu
Non-group intervention group:One-to-one supervision by experimenters at home for 1-2 weeks, and then it can be reduced to once every two weeks or spot checks. Carry out home training for 90min minutes
conventional care group:Health education for staff at home or by telephone.
Sponsors
Jiangsu Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. People aged 45-85; 2. Compared with the previous normal state, the cognitive function of self-feeling is declining, mainly in memory, and has nothing to do with acute events; 3. The individual objective neuropsychological test is normal or fails to meet the diagnostic criteria of MCI; 4. Primary school education or above; 5.Lubben Social Network Scale (LSNS) LSNS-6 is a simplified version, which includes SCD people with a score of 0-12, that is, SCD people who are socially isolated. 6.Informed consent shall be provided by the participant or their legal guardian
Exclusion criteria
Exclusion criteria: 1. Patients with vascular dementia or other organic brain diseases; 2. Modified Hachinski Ischemia Scale score > 4; 3. Those with blindness, deafness, severe speech disorders, etc. who cannot cooperate with cognitive function examination; 4. Those who have a history of drug or alcohol dependence and other substances within the past 6 months; 5. Participating in other cognitive-related clinical studies. 6. Patients are complicated with severe diabetes, cardiovascular diseases, liver diseases, kidney diseases, mental diseases, bone and joint diseases and other diseases; 7. Those who are unable to undergo fMRI due to claustrophobia, metal foreign bodies in their bodies, dentures, etc. 8. Suffering from other diseases and unable to participate in aerobic training or cognitive function examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test Huashan Version,AVLT-H—N5;Resting-state functional magnetic resonance imaging,rs-fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination,MMSE;Montreal Cognitive Assessment,MoCA;trail making test,TMT-A,TMT-B;Wechsler Memory Scale-Revised Logical Memory,WMS-RLM;Wechsler Digit Span,WDS;animal fluency test,AFT;Bosten naming test,BNT;Lubben Social Networrk Scale,LSNS-6;Loneliness Scale,Univesity of California at Los Angels,UCLA;Geriatric Depression Scale,GDS;Insomnia Severity Index, ISI;Pittsburg Sleep Quality Index,PSQI;functional activities questionnaire,FAQ; | — |
Countries
China
Contacts
Public ContactZhu Yi
Jiangsu Provincial People's Hospital
Outcome results
None listed