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Identification of lymph node metastasis in colorectal adenocarcinoma based on LBX2 gene methylation in colorectal cancer patients

Identification of lymph node metastasis in colorectal adenocarcinoma based on LBX2 gene methylation in colorectal cancer patients

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400080295
Enrollment
Unknown
Registered
2024-01-25
Start date
2024-02-15
Completion date
Unknown
Last updated
2024-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer

Interventions

Lymph node metastasis group
Lymph node non-metastatic group:None

Sponsors

None
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Newly treated patients with no previous history of colorectal cancer surgery; 2. Age 18-75 years old; 3. Male or non-pregnant or lactating women; 4. Preoperative electronic colonoscopy pathological diagnosis of colorectal adenocarcinoma; 5. None of the selected patients received radiotherapy or chemotherapy before surgery; 6. The patient voluntarily signs the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Frozen pelvic cavity was found during surgery, which is difficult to remove during surgery; 2. Preoperative evaluation of the patient as an advanced patient and unable to undergo surgical treatment; 3. Patients who need neoadjuvant therapy before surgery; 4. Postoperative pathological non-colorectal adenocarcinoma; 5. The number of lymph nodes sent for examination in the negative group of colon cancer lymph nodes did not reach 12; 6. Patients with incomplete clinical data (including TNM stage, tumor volume, pathological classification, site of occurrence, vascular invasion, age, gender, depth of invasion, degree of differentiation, history of drinking, smoking, etc.).

Design outcomes

Primary

MeasureTime frame
LBX2 methylation levels of the tumor tissue;lymph node metastasis;

Countries

China

Contacts

Public ContactCui Chunhui

Zhujiang Hospital, Southern Medical University

drcuich@163.com+86 135 7054 1388

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026