Patients undergoing major thoracic and abdominal surgery
Conditions
Interventions
E group:After anesthesia induction, the test group was pumped with 1 g / L esketamine with an infusion rate of 0.5 mg·kg-1·h-1
N group:After anesthesia induction the control group an equal volume of saline at the equal rate(0.5 ml·kg-1·h-1)
Sponsors
Taizhou Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) age 18 years and <80 years, 2) patients receiving postoperative analgesia due to major thoracic and abdominal surgery, 3) ASA grade I-III, 4) voluntary participation in the study and signed informed consent
Exclusion criteria
Exclusion criteria: ? Patients with allergy to esketamine drugs and contraindications, Including elevated intracranial pressure, severe hypertension (grade III hypertension, poorly controlled, or untreated hypertension), glaucoma, untreated, or undertreated hyperthyroidism patients; ? Combined with severe cardiovascular diseases (such as myocardial infarction, heart failure, malignant arrhythmia, etc.), kidney disease, liver disease (serum total bilirubin 34.2 µ mol/L); ? Have taken antidepressants or received other interventions in the last 4 weeks; ? Patients with moderate or above anemia (Hb <90 g / L); ? Long-term use of sedative drugs, analgesics, long-term alcoholism; ? The presence of neurocognitive dysfunction, Self-rated or controlled pain analgesia cannot be performed.? Unable to understand the cooperation or refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| POD;Qor-15; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;NSE; | — |
Countries
China
Contacts
Public ContactTaotao Wang
Taizhou Municipal Hospital
Outcome results
None listed