The Effect of prophylactic Ondansetron on the Incidence of Hypotension after Spinal Anesthesia in Pre-eclampsia Women

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400080284

Enrollment

Unknown

Registered

2024-01-25

Start date

2024-02-01

Completion date

Unknown

Last updated

2024-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preeclampsia

Interventions

Ondansetron group:4mg ondansetron pre-injection

Saline group:the same volume of saline

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 120 cases of preeclampsia undergoing cesarean section. The age ranged from 18 to 35 years old, with ASA III grade and body mass index (BMI) ranging from 18 to 35 kg/m.

Exclusion criteria

Exclusion criteria: (1) Multiple pregnancy; (2) mental illness; (3) Contraindications of spinal anesthesia (patient's refusal, increased intracranial pressure, hypovolemia, abnormal coagulation function, etc.); (4) Patients with serious cardiovascular and cerebrovascular diseases, endocrine and respiratory diseases.

Design outcomes

Primary

Measure	Time frame
Blood Pressure (incidence of hypotension);	—

Secondary

Measure	Time frame
Dose requirement of phenylephrine;side effects;Umbilical artery blood gas analysis;	—

Countries

China

Contacts

Public ContactFei Xiao; Qiang Xu

Jiaxing Maternity and Child Health Care Hospital

13706597501@163.com+86 137 0659 7501

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026