acute myocardial infarction
Conditions
Interventions
Placebo:not
Experimental group:Nicoridil
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: All patients were treated with emergency PCI for acute anterior wall ST-segment elevation myocardial infarction. 1)Age 18-80 years old; 2) Patients with clinically diagnosed STEMI within 12 hours of onset are scheduled to undergo emergency PCI; 3) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Systolic blood pressure <100mmHg; 2) Cardiogenic shock; 3) Combined with aortic dissection; 4) Myocardial infarction or revascularization (PCI or CABG) within 6 months; 5) Currently receiving nicorandil treatment; 6) Patients taking intravenous nitrates before surgery; 7) Have any known allergic reaction, hypersensitivity reaction or contraindication to nicorandil; 8) Participating in other studies currently or within three months; 9) Pregnant and lactating women; 10) Cancer patients whose expected survival time is less than 1 year; 11) Those with severe mental disorders and unable to express their wishes; 12) There are other obvious abnormal signs, laboratory tests and clinical diseases, and according to the judgment of the researcher, they are not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cytokines(IL-1ß?IL-2?IL-5?IL-6?IL-8?IL-12p70?IL-17?TNF-a?IFN-??IFN-a?IL-4?IL-10); | — |
Secondary
| Measure | Time frame |
|---|---|
| LVEF;Blood routine, hypersensitivity C-reactive protein;Percentage decrease in the ST segment of the ECG;NT-proBNP; | — |
Countries
CHINA
Contacts
Public ContactFeng chunguang
Xuzhou Central Hospital
Outcome results
None listed