Abnormal growth and development in the children
Conditions
Interventions
Gold Standard:Radiological bone age, evaluated using TW3-C-RUS (Chinese 05 method) after X-ray examination of the left hand and left wrist in children. A difference of more than 2 years between radiol
Index test:Ultrasonic bone age. After examining the target area with ultrasound, the ossification rate is calculated. This ossification rate is then input into the mathematical model obtained from the
Sponsors
People’s Hospital of Chongqing Liang Jiang New Area
Eligibility
Sex/Gender
All
Age
No minimum to 19 Years
Inclusion criteria
Inclusion criteria: 1. Preceding Group: Patients aged 0-19 whose height and weight within the 3-97 percentile of the Chinese children's growth curve, with no abnormal parental height, no history of trauma, surgery, or other diseases that could cause abnormal bone age. 2. Modeling Group: Preschoolers and students aged 2-19, meeting the same criteria as the preceding group. 3. Validation Group: Inclusion criteria comprise clinically suspected cases of abnormal bone age in children aged 2-19.
Exclusion criteria
Exclusion criteria: Preceding and Modeling Groups: 1. Wrist/knee joint developmental abnormalities; 2. History of bone/joint trauma; 3. Arthritis; 4. Thyroid dysfunction; 5. Precocious puberty; 6. Other diseases that may lead to abnormal bone age. Validation Group: Not undergone X-ray or ultrasound bone age examination within the past week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasound-based ossification rate;sensitivity;positive predictive value;specificity;negative predictive value; | — |
Countries
China
Contacts
Public ContactXiong Yi Jun
People’s Hospital of Chongqing Liang Jiang New Area
Outcome results
None listed