Breast disease
Conditions
Interventions
Intervention Group:On the 14th and 15th postoperative days, 2 ml and 1 ml of PA-MSHA were injected through the drainage tube, and then 8 ml and 9 ml of normal saline(NS) were injected to flush the tub
Control Group:On the 14th and 15th postoperative days, 2 ml and 1 ml of phosphate buffered saline(PBS) were injected through the drainage tube, and then 8 ml and 9 ml of normal saline(NS) were injec
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Those who voluntarily participate in the trial and sign the written informed consent; 2)Female patients with primary breast cancer without severe underlying diseases such as heart, lung, brain, etc., and without distant metastases such as bone, lung, and liver; 3) Those who have undergone mastectomy and have not reached the indication of removing the drainage tube for 14 days after the operation.
Exclusion criteria
Exclusion criteria: 1) Women during pregnancy or breastfeeding; 2) Patients with immediate breast reconstruction after surgery; 3) Those who have severe uncontrolled medical diseases or acute infections prior to surgery; 4) Those who develop postoperative infection in the incision area; 5) Those with multiple drug allergies; 6) Other conditions that the investigator considers inappropriate for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative indwelling time of drainage tubes;Daily Drainage Fluid Volume and Total Drainage Fluid Volume;Incidence of seroma after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative complications (short-term safety);Local recurrence rate, distant metastasis rate, and mortality rate within 5 years after surgery (long-term safety);Postoperative quality of life (quality of life score);Number of postoperative medication dressing changes, dressing change costs and related transportation costs (economics); | — |
Countries
China
Contacts
Public ContactZhenggui Du
West China hospital, Sichuan University
Outcome results
None listed