Lumbar Disc Herniation
Conditions
Interventions
Spinal Anesthesia (SA) Group:Subarachnoid injection of 7.5 mg ropivacaine (0.125% 6 ml)
Local Anesthesia with Sedation (LAS) Group:Surgical area local anesthesia+target oriented personalized dosing regimen of dexmedetomidine
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) PELD surgery with transforaminal approach for single-level lumbar disc herniation; 2) Age 18 years and above; 3) ASA = 3 points;
Exclusion criteria
Exclusion criteria: 1) PELD surgery with interlaminar approach; 2) allergies to anesthetic and sedative drugs; 3) spinal anesthesia is expected to be infected at the puncture site; 4) Abnormal coagulation function, long-term use of anticoagulant drugs without discontinuation; 5) Obvious calcification of intervertebral disc, obvious lumbar deformity, lumbar spinal stenosis, lumbar spondylolisthesis, lumbar spondylolysis, lumbar spine infection, lumbar tuberculosis, lumbar tumor, history of previous lumbar spine surgery; 6) history of analgesic drug abuse (Misuse of prescription pain relievers); 7) Hepatic and renal insufficiency; 8) Those who are trying to get pregnant, pregnant or breastfeeding; 9) Mentally ill patients and vulnerable groups.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative back pain intensity (VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative VAS score for back and leg pain at multiple time points;Intraoperative analgesics use;Postoperative VAS score for back and leg pain at multiple time points;Postoperative analgesics use;Life of qualitu outcomes; | — |
Countries
China
Contacts
Public ContactSun Haolin
Peking University First Hospital
Outcome results
None listed