Premature ovarian insufficiency
Conditions
Interventions
treatment group:Four capsules of Yang Yin Shu Gan Capsules, tid, were given daily with warm water for 12 weeks.
control group:Yang Yin Shu Gan Capsules Placebo 4 capsules, tid, with warm water, were given daily for 12 weeks.
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: ?Those who meet the above diagnosis of Chinese and Western medicine; ? 18kg/? <BMI<24kg/? ; ?18 years old< age <40 years old; ?No hormone therapy in the past 3 months, selective estrogen receptor modulators or aromatase inhibitors, soybean extracts or herbs; ? Those who have no requirement for childbearing and are strictly contraceptive during the treatment period; ?Those who have signed the informed consent form.
Exclusion criteria
Exclusion criteria: ?Those who have a history of the following gynecological pelvic surgeries: ovarian cyst removal, ovarian perforation, ovarian wedge resection, adnexectomy, salpingo-oophorectomy, tubectomy, tubal ligation, pelvic abscess surgery, uterine artery embolization, etc. or those who have used reproduction-toxicity medications, such as lei gong teng, kunming shan hae teng, torches flower root tablets, and chemotherapeutic drugs; ? other endocrine disorders caused by menstrual disorders, such as hyperprolactinemia, endometriosis, polycystic ovary syndrome and thyroid disease; (iii) Organic pathologies such as malformations of the reproductive tract, congenital glandular insufficiency and uterine amenorrhea; (iv) Uncontrollable and/or diagnostic medical conditions that may interfere with or affect the study treatment, e.g., severe liver, kidney, heart, and brain diseases; patients with malignant tumors; and persons with severe mentally disabling disorders; ? Pregnancy or lactation; ? Combination of certain allergic diseases such as asthma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| menstrual score;serum sex hormone level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modification of the KI scale;SDS Scale;SAS Scale;Chinese Medicine Symptoms Scale;Anti-Müllerian tubular hormone;Gynecologic Vaginal Ultrasound;Serum 5-hydroxytryptamine;Serum norepinephrine;serum dopamine;lipids four;carotid ultrasound ;bone density;Procollagen I N-Terminal Propeptide;Beta-collagen special series; | — |
Countries
China
Contacts
Public ContactWang Xiaoyun
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed