Respiratory failure
Conditions
Interventions
ECMO group:No interventions, an observational study
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age = 18 years and = 80 years. (2) The patient or guardian voluntarily signs an informed consent form. (3) If one of the following conditions is met. 1. ARDS patients: lung-protective ventilation (Vt 6ml/kg, PEEP = 10cm H2O) combined with recruitment maneuver, prone position ventilation, or high frequency oscillation ventilation with PaO2/FiO2 600 mmHg under pure oxygen inhalation; or respiratory rate > 35 breaths/min,pH 30 cmH2O, with VV-ECMO adjuvant therapy. 2. Lung transplantation patients with ECMO support during perioperative period. 3. Asthma patients: under invasive mechanical ventilation support, platform pressure > 35cmH2O concomitant with severe respiratory acidosis (pH<7.1), or unstable hemodynamics, perform VV-ECMO or ECCO2R adjuvant therapy if there is no contraindication to ECMO, 4. Chronic Obstructive Pulmonary Disease (COPD): to enable patients with severe COPD requiring invasive ventilation to avoid intubation, or to assist in evacuation of tracheal intubation, perform ECMO adjuvant therapy;. 5. Perioperative ECMO support for elective surgeries such as high-risk or complex tracheobronchial surgeries and high-risk or complex pneumonectomies; 6. Patients judged by the investigator to be eligible for this study, such as thoracic surgery patients with high perioperative risk and prophylactic use of ECMO for perioperative safety.
Exclusion criteria
Exclusion criteria: (1) Age 80 years. (2) Duration of positive pressure ventilation with tracheal intubation for more than 7 days prior to admission. (3) Combination of severe irreversible end-stage disease, such as cancer, end-stage of the livercirrhosis, etc. (4) Irreversible multiorgan failure. (5) Combined cerebrovascular events such as severe cognitive impairment, cerebral haemorrhage or stroke occurring within 3 months. (6) Severe coagulopathies or bleeding disorders, or the presence of contraindications to anticoagulation, or inability to administer systemic anticoagulation. (7) Patients who are pregnant or breastfeeding. (8) Severe peripheral vascular disease or difficulty with ECMO placement. (9) With other untreatable end-stage disease. (10) Other inappropriate conditions for this study in the opinion of investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation;ECMO duration;Length of stay in ICU;Length of hospitalization;Mortality within 1-year after discharge;Systemic and localized bleeding;ECMO-related thrombosis;Ventilator-associated pneumonia;ventilator-induced lung injury;catheter-related bloodstream infection; | — |
Countries
China
Contacts
Public ContactQingyuan Zhan
China-Japan Friendship Hospital
Outcome results
None listed