Sedation for pediatric magnetic resonance imaging examinations
Conditions
Interventions
Esketamine group(modified sequential method):The nasal dose of dexmedetomidine was 1ug/kg, and the nasal dose of esketamine was arranged in a dose gradient of 0.1mg/kg on an equal scale, with an ini
if the sedation was ineffective, the next case's dose was increased by one gradient, and the process was repeated until 7 exchange points were observed. The lower limit of esketamine nasal dose was 0
Dexmetomidine group (modified sequential method):The nasal dose of esketamine was the ED95 dose measured in the first stage(modified sequential method), and the nasal dose of dexmedetomidine was arran
if the sedation was ineffective, the next case's dose was increased by one gradient, and the procedure was repeated until 7 exchange points were observed. The lower limit of dexmedetomidine nasal dose
Esketamine group (biased coin sequential method):The nasal dose of dexmedetomidine was 1ug/kg, and the nasal dose of esketamine was arranged in a dose gra
Sponsors
Children's Hospital , Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 3 Years
Inclusion criteria
Inclusion criteria: (1) aged from 1 month to 3 years old, regardless of sex; (2) children undergoing a single-site MRI examination and requiring sedation; (3) ASA grade ? ~ ?; (4) informed consent signed by family members; (5) no history of severe upper respiratory tract obstruction.
Exclusion criteria
Exclusion criteria: (1) nasal mucosal injury; (2) severe upper respiratory tract infection; (3) allergy to dexmedetomidine, esketamine, or ketamine; history of failure of deep sedation (4) mental or consciousness disorders; autism or autism (5) cardiac arrhythmias, especially those with chronic arrhythmias; (6) severe obesity (weight =50% above standard weight); (7) The patient's family rejected the proposal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 95% effective dose of intranasal dexmetomidine combined with esketamine for pediatric MRI sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Pulse oxygen saturation;Respiratory rate;Sedation onset time ;Sedation maintenance time;Length of PACU stay; | — |
Countries
China
Contacts
Public ContactYaoqin Hu
Children's Hospital, Zhejiang University School of Medicine
Outcome results
None listed