Effect of different ventilation modes on postoperative pulmonary complications in elderly patients undergoing laparoscopic surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400080076

Enrollment

Unknown

Registered

2024-01-19

Start date

2024-01-22

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing general anesthesia surgery

Interventions

Group V:volume controlled ventilation (VCV) mode is used

Group P:Pressure controlled ventilation (PCV) mode is used

Eligibility

Sex/Gender

All

Age

65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1.Undergoing laparoscopic surgery; 2.Aged 65 to 85 years old; 3.The American Society of Anesthesiologists (ASA) is classified as Grade I-III; 4.Expected mechanical ventilation time > 3 hours.

Exclusion criteria

Exclusion criteria: 1.Emergency surgery; 3.BMI > 30kg/m2; 3.Acute heart failure; 4.Severe hepatic and renal insufficiency (Child-Pugh grade B, C, creatinine > 200 mmol/L or glomerular filtration rate < 30ml/min); 5.Patients who underwent general anesthesia or mechanical ventilation in the last 2 weeks.

Design outcomes

Primary

Measure	Time frame
Postoperative pulmonary complications;	—

Secondary

Measure	Time frame
The concentration of CC16 and SP-D in serum;Serum indicators (PRDX6 protein and inflammatory factors such as TNF-a, IL-1ß and IL-6);Indicators in BALF (contents of PRDX6 protein and inflammatory factors such as TNF-a, IL-1ß and IL-6);Intraoperative respiratory mechanics;	—

Countries

China

Contacts

Public ContactShen Qiying

The First Affiliated Hospital of Anhui Medical University

shenqiying-yy@163.com+86 139 5602 9032

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026