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Anti-VEGF drugs combined with dexamethasone implant for macular edeam secondary to retinal vein occlusion

Anti-VEGF drugs combined with dexamethasone implant for macular edeam secondary to retinal vein occlusion - Anti-VEGF drugs combined with DEX for ME secondary to RVO

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400080048
Enrollment
Unknown
Registered
2024-01-18
Start date
2024-01-18
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

macular edeam secondary to retinal vein occlusion

Interventions

the ranibizumab group : The ranibizumab group, The patients received ranibizumab intravitreal injections in the first three months as the initial treatment. Patients might receive repeat injections d
The recurrence of macular edema is defined as the central macular thickness = 300 um, or the increase of central macular thickness = 50 um from the baseline.
the combination group:The combination group (ranibizumab combined with dexamethasone intravitreal implant). In the combination group, patients received an intravitreal injection of dexamethasone impla

Sponsors

Sanmenxia Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
42 Years to 79 Years

Inclusion criteria

Inclusion criteria: Patients over 18 years of age with retinal vein occlusion and macular edema confirmed by OCT and FFA, Patients with optimal corrected visual acuity between 1.30-0.30(LogMAR visual acuity) ; OCT shows CMT=290um, patients with new onset within 3 months who had not received anti-VEGF drugs or laser therapy before onset; Patients with good compliance and no obvious surgical contraindications by auxiliary examination.

Exclusion criteria

Exclusion criteria: Patients with other retina-related diseases, such as diabetic retinopathy, age-related macular degeneration, retinal vasculitis, etc. Previous history of glaucoma, ocular trauma and high myopia; Patients with severe cataract or vitreous hematocele and other refractive interstitial opacity affecting fundus imaging; History of stroke or myocardial infarction, or severe unstable systemic disease.

Design outcomes

Primary

MeasureTime frame
Median LogMAR Visual Acuity;Central macular thickness;

Secondary

MeasureTime frame
Number of recurrence of ME(times);Mean time(days);number of injections (times);

Countries

China

Contacts

Public ContactXiaohui Cai

Sanmenxia Eye Hospital

1091849223@qq.com+86 186 3115 2454

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026