epilepsy
Conditions
Interventions
DBS:DBS therapy
Sponsors
the Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age: The age range of the subjects is 14 to 70 years old. Clinical diagnosis of epilepsy: Participants must be diagnosed with drug-resistant epilepsy. The diagnosis will be based on established diagnostic criteria, such as the International League Against Epilepsy (ILAE) epilepsy classification system. Disease severity: The Global Assessment of Severity of Epilepsy (GASE) Scale4 is used to assess the severity of seizures in subjects using the epilepsy rating scale. Previous treatment: Participants should undergo drug trials, physical therapy, or other standard treatments for epilepsy for at least two years. Recording past treatments can evaluate treatment outcomes and potential impacts on the long-term efficacy of DBS. Preoperative evaluation: including detailed medical history collection, long-term video electroencephalography of 3 or more clinical seizures, epilepsy series MR examination, and PET-MR examination. After multidisciplinary consultation (MDT), it was determined that epilepsy could not be surgically removed, or seizures still occurred after surgical removal. Willingness to undergo DBS surgery: Participants must indicate their willingness to undergo DBS surgery as a treatment option. Informed consent will be obtained to ensure that participants fully understand the risks, benefits, and alternative treatment options associated with DBS. Participants who are unwilling to undergo surgical intervention will be excluded from the study. Other factors: In the selection process, other factors such as overall physical health, cognitive function, and medication history need to be considered to ensure the safety of participants and the universality of research results. These factors will be screened through medical records, physical examinations, cognitive assessments, and interviews.
Exclusion criteria
Exclusion criteria: 1) There is a significant cognitive impairment that can affect the patient's daily living abilities (such as social, work, and medication use). 2) Clearly severe (refractory) mental illnesses such as depression, anxiety, and schizophrenia. 3) Clearly coexisting medical diseases affect surgery or survival.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of epilepsy symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of cognitive function;Improvement of psychological and mental disorders; | — |
Countries
China
Contacts
Public ContactXiao Qihua
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed