Postoperative delirium
Conditions
Interventions
Group L:Maintain intraoperative MAP at moderate low level 75-90mmHg
Group M:Maintain intraoperative MAP at middle level 90-105mmHg
Group H:Maintain intraoperative MAP at moderate high level 105-120mmHg.
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Preoperative primary hypertension (non-invasive cuff pressure measurement, systolic blood pressure = 140mmHg or diastolic blood pressure = 90mmHg; or taking antihypertensive drugs); 2. Age range from 60 to 80 years old; 3. Planned to undergo elective surgery for gastrointestinal, pancreatic, esophageal, gynecological, and urinary system tumors, with an expected anesthesia duration of = 3 hours; 4. ASA II-III level, NHYA I-II level; 5. Internal jugular vein puncture and catheterization required
Exclusion criteria
Exclusion criteria: 1. Preoperative cognitive impairment, dementia, delirium, etc; 2. Preoperative serious mental illness or neurological disorders, or abuse of psychotropic drugs; 3. Severe visual and auditory impairment or inability to engage in normal verbal communication; 4. Alcohol abuse (male average daily pure alcohol intake = 61 g, female average daily pure alcohol intake = 41 g, pure alcohol consumption (g)=alcohol consumption (ML)) × Alcohol content% × 0.8); 5. Preoperative Mini Mental State Examination (MMSE) scale evaluation indicates difficulty in cooperating with testers (based on corresponding educational levels, primary education level = 20 points, secondary education level = 22 points, and university education level = 23 points); 6. Controlled hypotension is required during surgery; 7. Diagnosed or undetermined secondary hypertension, urgent hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Delirium ;Postoperative agitation in operation room;Postoperative cognitive disorders;NRS score at rest;NRS score at cough ;Delirium with drug treatment;Postoperative nausea;Postoperative vomiting;Surgery blood loss;Postoperative drainage volume;Hemoglobin decrease; | — |
Countries
China
Contacts
Public ContactNi Cheng
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Outcome results
None listed