A double-blind, randomized, controlled clinical study of high-frequency rTMS for the treatment of post-stroke executive dysfunction

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400080023

Enrollment

Unknown

Registered

2024-01-18

Start date

2024-03-01

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

rTMS group:repetitive transcranial magnetic stimulation (rTMS)

sham group:sham repetitive transcranial magnetic stimulation

Healthy control group:None

Eligibility

Sex/Gender

All

Age

35 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) Inclusion criteria for PSEI subjects: ? Primary ischemic and hemorrhagic stroke; ? The lesion is located in the cortex and subcortex of the cerebral hemisphere; ? Duration of the disease 1-12 months; ? The lesion is located in the cortex or subcortex of the cerebral hemisphere; ? Presence of mild or moderate cognitive impairment (10 points = MoCA <26 points); ? Vital signs are stable without progressive neurological symptoms; ? No severe aphasia, visual or auditory impairment, right-handed, able to complete paper and pencil tests; ? If using cognitive improvement drugs (e.g., donepezil, memantine) for at least 3 weeks or more, no further dose adjustments will be made during enrollment; ? Voluntary participation and signing of informed consent. (2) Inclusion criteria for healthy subjects: ? Age 40-75 years old, right-handed; ? No abnormality in fMRI examination of the head; ? No cognitive dysfunction, MoCA score =26; ? No medication.

Exclusion criteria

Exclusion criteria: PSEI, Healthy Subjects Exclusion Criteria: ? Pre-existing history of brain tumor, traumatic brain injury, epilepsy or mental disorder; ? Cognitive impairment prior to stroke; ? Post craniotomy/cranial defects; ? Metal or electronic device implants (e.g., pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal shunts, etc.); ? Inability to cooperate in completing assessment tests and rTMS interventions.

Design outcomes

Primary

Measure	Time frame
Wisconsin Card Sorting Test;	—

Secondary

Measure	Time frame
Montreal Cognitive Assessment;Stroop Color Word Test;Trail Making Test;Digital Span Test;Activities of Daily Living Scale;	—

Countries

China

Contacts

Public ContactLiu Yuanwen

The Third Affliated Hospital of Sun Yat-Sen University

lywkangfu@163.om+86 131 8915 9359

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026