Effect of low-dose naloxone on extubation time after general anesthesia: A prospective randomized controlled clinical trial

Strategies for rapid recovery and extubation after general anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400080013

Enrollment

Unknown

Registered

2024-01-18

Start date

2024-01-25

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

recovery and extubation after general anesthesia

Interventions

Experimental group:Naloxone 0.25 µg/kg (3 ml) and sugammadex sodium IV postoperatively

Control group:Saline 3ml and sugammadex sodium IV postoperatively

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with laparoscopic cholecystectomy under general anesthesia, aged 18 to 65 years, with American Society of Anesthesiologists (ASA) classification I to II.

Exclusion criteria

Exclusion criteria: ? Patients with abnormal heart, brain, lung, liver and kidney function; ? BMI=28kg/m2.

Design outcomes

Primary

Measure	Time frame
Anesthesia recovery time;	—

Secondary

Measure	Time frame
Extubation time;5-minute extubation rate in the operating room;Stay length in PACU;Postoperative pain score;The incidence of delirium and emergence agitation;The incidence of hypertension and hypotension;The incidence of PACU hypoxian;Incidence of analgesic administration in the PACU;	—

Countries

China

Contacts

Public ContactGuang-qiu Zhu

Taizhou Hospital of Zhejiang Province

inchina888999@163.com+86 137 5760 9305

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026