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A real-world observation study on the efficacy evaluation of ADT combined with NHA in neoadjuvant therapy for high-risk localized prostate cancer

A real-world observation study on the efficacy evaluation of ADT combined with NHA in neoadjuvant therapy for high-risk localized prostate cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400080012
Enrollment
Unknown
Registered
2024-01-18
Start date
2024-02-01
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prostatic cancer

Interventions

Experimental group :During the neoadjuvant treatment period, subjects were intramuscularly injected with Goserellin microspheres: 3.6mg, once a month, and orally administered NHA (unspecified drug) fo

Sponsors

The First Affiliated Hospital of Xinjiang Medical University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age = 18 years old 2. Pathological diagnosis of prostate cancer 3. Clinical staging of T2c-T4NxM0 with Gleason ps>7 4. Planned neoadjuvant therapy combined with radical prostatectomy according to guidelines 5. ECOG score = 1 point 6. No other medication treatment received

Exclusion criteria

Exclusion criteria: 1. Pathological diagnosis of urinary tract epithelial origin; 2. Pathological diagnosis of neuroendocrine tumor; 3. Pathological diagnosis of intraductal carcinoma; 4. Received any other anti-tumor treatment 6 months prior to enrollment.

Design outcomes

Primary

MeasureTime frame
pathologic complete response rate;

Secondary

MeasureTime frame
Positive margin rate;disease-free survival;overall survival;adverse reactions;

Countries

China

Contacts

Public ContactQianjin Li

The First Affiliated Hospital of Xinjiang Medical University

1529289279@163.com+86 152 9285 9279

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026