The role of iron death in postoperative cognitive impairment in patients undergoing cardiac surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400079977

Enrollment

Unknown

Registered

2024-01-17

Start date

2024-01-27

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive dysfunction

Interventions

POCD group:None

The POCD group did not occur:None

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) ASA classification I.~III. (2) Age= 18 years old; (3) 18.5=BMI=24, (4) patients undergoing elective CPB cardiac surgery, (5) no history of secondary surgery, and (6) 24 points of preoperative Mini-Mental State Examination (MMSE) >.

Exclusion criteria

Exclusion criteria: (1) History of neurological or psychiatric diseases, severe liver and kidney insufficiency, and stroke; (2) frequent use of painkillers or antidepressants before surgery; (3) Drug abuse or psychotropic drug abuse, long-term use of steroid drugs and hormone drugs; (4) Those who refuse to participate in this study or their family members.

Design outcomes

Primary

Measure	Time frame
Glutathione Peroxidase 4;Solute carrier family 7 member 11;Malondialdehyde;Reduced glutathione/oxidizided glutathione;	—

Countries

China

Contacts

Public ContactDai Qinxue

The First Affiliated Hospital of Wenzhou Medical University

653091408@qq.com+86 136 9584 2272

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026