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o investigate the epigenetic mechanism of Erzhitiangui decoction in inhibiting granulosa cell apoptosis based on lncNEAT1: the effect of Erzhitiangui decoction on programmed cell death of ovarian granulosa cells in patients with DOR

o investigate the epigenetic mechanism of Erzhitiangui decoction in inhibiting granulosa cell apoptosis based on lncNEAT1: the effect of Erzhitiangui decoction on programmed cell death of ovarian granulosa cells in patients with DOR

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400079975
Enrollment
Unknown
Registered
2024-01-17
Start date
2024-01-20
Completion date
Unknown
Last updated
2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diminished Ovarian Reserve

Interventions

treatment group:Erzhi Tiangui prescription
control group:Placebo
Blank control group:NONE

Sponsors

The Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Meeting the diagnostic criteria for DOR; 2. meeting the diagnostic criteria of TCM kidney deficiency syndrome; 3. body mass index (BMI) is 18-25 kg/m2; 4.Women aged 20-40years ; 5. No use of hormone drugs for the first three months of treatment; 6. Willing to sign an informed consent form and voluntarily participate in the trial; 7. Approved by the Ethics Committee; 8. Comply with the Human Assisted Reproductive Technology Specification

Exclusion criteria

Exclusion criteria: 1. Those who do not follow the doctor's advice or are allergic to the ingredients of this Chinese medicine; 2. History of gynecological malignancy or radiotherapy/chemotherapy; 3. Infertility caused by genetic factors; 4. History of recurrent abortion; 5. The female reproductive tract has abnormal anatomical structure and does not have pregnancy function; 6. The woman is suffering from serious physical or mental illness and cannot bear pregnancy

Design outcomes

Primary

MeasureTime frame
Number of oocytes retrieved;

Secondary

MeasureTime frame
basal serum sex hormones;Rate of MII oocytes;Rate of 2 pronuclei (PN) fertilizations;Traditional Chinese Medicine syndrome score;Rate of High quality embryo ;Clinical pregnancy rate;

Countries

China

Contacts

Public ContactWu haicui

The Affiliated Hospital of Shandong University of Traditional Chinese Medicine

haicui_w@163.com+86 150 6912 9571

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026