CHB, acute-on-chronic liver failure
Conditions
Interventions
This study is a prospective observational study and does not involve different interventions groups or clinical features
:All patients received routine clinical treatment and completed liver reserve function testing. Liver reserve function testing is also a mature and commonly used liver function testing method in clini
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age range from 18 to 75 years old, regardless of gender; (2) The diagnostic criteria of HBV-ACLF refer to the Guidelines for the Diagnosis and Treatment of Liver Failure (2018 version), and the diagnostic criteria of chronic viral hepatitis B refer to the Guidelines for the Diagnosis and Treatment of Chronic Hepatitis B (2022 version): on the basis of chronic hepatitis B virus infection, acute or subacute clinical symptoms of decompensation of liver function occur in a short period of time, which are manifested as: ? extreme fatigue with obvious gastrointestinal symptoms; ? Jaundice rapidly deepens, with serum total bilirubin exceeding the upper limit of normal by 10 times or daily increase of = 17.1 µ Mol/L; ? Bleeding tendency, PTA = 40% (or INR = 1.5), and excluding other causes; ? Decompensated ascites; ? Accompanied or not accompanied by hepatic encephalopathy.
Exclusion criteria
Exclusion criteria: Concomitant hepatitis A, hepatitis C, hepatitis D, and hepatitis E, combined with CMV and EBV infections, combined with hyperthyroidism and autoimmune diseases, combined with severe heart, lung, and kidney dysfunction or malignant tumors, combined with HIV infection, combined with pregnancy, previous history of heavy alcohol consumption, recent history of using anti tuberculosis drugs, recent intake of traditional Chinese medicine, weight loss drugs, and various health products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival outcome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of readmissions; | — |
Countries
China
Contacts
Public ContactZHU XIA
West China Hospital of Sichuan University
Outcome results
None listed