hypoxemia
Conditions
Interventions
lidocaine group:Lidocaine 1.5 mg/kg was injected intravenously and continued at a rate of 2 mg/kg/h until the end of the procedure
control group:The same volume of normal saline was injected intravenously, and the same amount of normal saline was continued during the operation until the end of the operation.
Sponsors
The Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years old,18<BMI < 28 Kg/?; 2. ASA is graded from ? to ?; 3. Patients who intend to undergo bronchoscopic surgery under general anesthesia (endoscopic biopsy and/or brush examination, alveolar perfusion, Ebus-TBNA, Ebus-TBLB, endoscopic resection of airway lesions); 4. The informed consent for the study has been signed;
Exclusion criteria
Exclusion criteria: 1.severe cardiopulmonary dysfunction, such as hypoxemia (resting state SPO2< 90%), chronic arrhythmias (HR< 50/min), hypotension (MAP< 60 mmHg), New York Heart Association (NYHA) classification =?, history of conduction block, etc. 2. Exacerbation of COPD or recent acute upper respiratory tract infection; 3. Pregnancy or lactation; 4. Preoperative cognitive dysfunction; 5. Abnormal liver and kidney function; 6. Allergic to narcotic drugs and opioids; 7. Use of local anesthetics in the past 24 hours; 8. Participated in other clinical studies within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spo2; | — |
Secondary
| Measure | Time frame |
|---|---|
| interleukin-6;interleukin-8;Changes in hemodynamics;Coughing frequency;Adverse event occurrence rate; | — |
Countries
China
Contacts
Public ContactZhang Qian
The Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)
Outcome results
None listed