sepsis
Conditions
Interventions
experimental group:Both groups followed the clinical guidelines, improved pathogenic microorganism monitoring, clearance of infection, early use of antibiotics and hemodynamic support. On this basis,
control group:All patients followed the clinical guidelines, improved pathogenic microorganism monitoring, clearance of infection foci, early use of antibiotics and hemodynamic support.
Sponsors
Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
18 Years to 150 Years
Inclusion criteria
Inclusion criteria: Diagnostic criteria: (1) sepsis infection + SOFA score two points or more (2) age 18 years old or more,
Exclusion criteria
Exclusion criteria: ? Bleeding tendency and DIC before enrollment; ? Organ failure occurred before enrollment; ? Advanced malignant tumor and cachexia; (4) (5) when the disease in patients with pregnancy or lactation; ? known to be allergic to heparin or heparin-like substances.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heparan sulfate;Syndecan-1;coagulation function;inflammatory factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Acute physiology and chronic health Evaluation;Sequential organ failure assessment score;ICU mortality and 28-day mortality; | — |
Countries
china
Contacts
Public ContactLeqingLin
Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed