open abdomen
Conditions
Interventions
Part one: early stage of open abdomen without enterocutaneous fistula:Temporary abdominal closure by mesh pulling
Part one: Control group:None
Part two: early stage of open abdomen with enterocutaneous fistula:Temporary abdominal closure assisted by vacuum negative pressure
Part Two: Control group:None
Sponsors
General Hospital of Eastern Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Part one: early stage of open abdomen without enterocutaneous fistula (1) Age = 18 and = 80; (2) OA patients without frozen abdomen (without combined EAF); (3) Subjects voluntarily participate in relevant trials, and subjects or guardians must sign an informed consent form (ICF) to indicate their understanding of the purpose and required procedures of the relevant research. Part two: early stage of open abdomen with enterocutaneous fistula (1) Age = 18 and = 80; (2) OA patients without frozen abdomen (combined with EAF); (3) Subjects voluntarily participate in relevant trials, and subjects or guardians must sign an informed consent form (ICF) to indicate their understanding of the purpose and required procedures of the relevant research.
Exclusion criteria
Exclusion criteria: (1) The wound is accompanied by uncontrollable bleeding; (2) Intestinal tract with tumor or tumor tissue infiltration nearby; (3) History of taking immunomodulatory drugs within 2 weeks; (4) There are ongoing research investigations or drug trials or no more than 30 days after completion; (5) Have mental illness and have difficulty communicating with medical staff; (6) With pregnancy; (7) Active or symptomatic viral hepatitis or other chronic liver disease, known infection with human immunodeficiency virus (HIV); (8) Heart disease of clinical significance, including: myocardial infarction or arterial thrombosis occurred in the past 6 months: severe or unstable angina pectoris: new York Heart Association grade III or IV heart disease: atrial fibrillation or other arrhythmias requiring treatment; (9) Patients can't follow the research strategy; (10) There are other circumstances in which the researcher considers it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time for the open abdominal wound to reach the condition of skin grafting; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of new enterocutaneous fistula in open abdominal wound;The time for the formation of a frozen abdomen;The incidence of complications such as fever, bleeding, and infection;Time for removing or replacing dressings;Pain from removing or replacing dressings;The total number of times of replacing dressings; | — |
Countries
China
Contacts
Public ContactRen Jianan
General Hospital of Eastern Theater Command
Outcome results
None listed