Gynecological operation
Conditions
Interventions
Remazolam group:Anesthesia induction: remazolam 0.3 mg/kg+ Sufentanil 0.5 ug/kg + rocuronium 0.6 mg/kg. A modified vigilance/sedation score (MOAA/S) was used to evaluate the depth of sedation during a
Propofol group:Anesthesia induction: Propofol 2.0 mg/kg+ Sufentanil 0.5 ug/kg + rocuronium 0.6 mg/kg. A modified vigilance/sedation score (MOAA/S) was used to evaluate the depth of sedation during an
Sponsors
Zunyi Maternal And Child Health Care Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) 18= age =65 years old, female patients. (2) ASA grade I~II. (3) 18 kg/m2=BMI=28kg/m2. (4) General anesthesia patients undergoing gynecological endoscopic surgery. (5) The patient voluntarily participated in the study and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Allergic or contraindicated to benzodiazepines, opioids, propofol, flumazenil, naloxone and other drugs and their drug components. (2) Acute heart failure. Unstable angina pectoris; Myocardial infarction occurred within 6 months before screening. Resting ECG heart rate < 50 beats/min; Severe arrhythmia; Moderate to severe heart valve disease. (3) Patients with severe respiratory diseases. (4) Patients who did not receive formal antihypertensive therapy or poorly controlled blood pressure (SBP=160 mmHg or SBP=90 mmHg during the screening period). (5) Abnormal liver and kidney function. (6) Craniocerebral injury, possible intracranial hypertension, brain aneurysm, cerebrovascular accident history and central nervous system diseases. (7) Patients with mental system diseases and long-term history of taking psychiatric drugs and cognitive impairment. (8) Participants in any clinical trial as subjects within 3 months prior to enrollment. (9) Other conditions determined by the researcher to be unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anterograde amnesia score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety score;Depression score; 6/5000 MMSE score; | — |
Countries
China
Contacts
Public ContactXue Zheng
Zunyi Maternal And Child Health Care Hospital
Outcome results
None listed