subacute liver function injury after partial hepatectomy in high-altitude areas
Conditions
Interventions
dexmedetomidine:Intraoperative intravenous administration of dexmedetomidine using a loading dose combined with continuous infusion
Control group:Intravenous administration of 0.9% sodium chloride at the same loading dose and continuous infusion rate
Sponsors
Qinghai Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria (Prior to the study, participants must meet all of the following requirements in order to be enrolled) 1 Age range from 18 to 70 years old, regardless of gender; 2 Permanent population in areas above 2500 meters above sea level; 3 Perform liver resection surgery in our hospital, and use Pringle technique for total hepatic portal block during the operation; 4 American Society of Anesthesiologists (ASA) classification I to III levels; 5 Participants are informed and voluntarily participate, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion criteria (prior to the study, subjects are not eligible for enrollment if they meet any of the following requirements): 1. Patients with severe heart, lung, brain, kidney and other important organ diseases; Patients with pulmonary dysfunction (PaO2<60mmHg) or concomitant chronic obstructive pulmonary disease; Patients with chronic diseases such as hypertension and diabetes; Patients with concomitant neurological and psychiatric disorders; Patients who have experienced severe myocardial infarction within the past three months; Rupture or bleeding of liver tumors; Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| liver function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal function;blood routine examination;Blood coagulation function;inflammatory factor;Hemodynamic indicators; | — |
Countries
China
Contacts
Public ContactWang Hongxia
Qinghai Provincial People's Hospital
Outcome results
None listed