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Discovery and clinical application of biomarkers for PARP Inhibitor efficacy and adverse reactions

Discovery and clinical application of biomarkers for PARP Inhibitor efficacy and adverse reactions

Status
Recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400079921
Enrollment
Unknown
Registered
2024-01-16
Start date
2023-03-05
Completion date
Unknown
Last updated
2025-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian cancer

Interventions

Case series:None

Sponsors

Sun Yat-sen University Cancer Center
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Signed Informed Consent Form (ICF) 2. Age = 18 years 3. Has histologically confirmed diagnosis of advanced epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer 4. high grade serous adenocarcinoma or endometrioid adenocarcinoma; 5. First-line platinum-containing chemotherapy or platinum-sensitive patients with platinum-based chemotherapy after the use of PARP inhibitor maintenance treatment;

Exclusion criteria

Exclusion criteria: Subjects meeting any of the following conditions should not be enrolled in this clinical study: (1) Histopathology indicating low-grade serous adenocarcinoma, mucinous adenocarcinoma, or carcinosarcoma; (2) Patients with concomitant primary tumors; (3) Concurrent use of other antitumor drugs; (4) Pregnant women; (5) HIV positive; (6) Deemed unsuitable for inclusion by the investigator.

Design outcomes

Primary

MeasureTime frame
Progression free survival;

Secondary

MeasureTime frame
adverse events;

Countries

China

Contacts

Public ContactLan Chunyan

Sun Yat-sen University Cancer Center

lanchy@sysucc.org.cn+86 20 8734 3104

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026